The Complexity of High-Density Lipoproteins Bela F. Asztalos, ... Brian Ishida, in The HDL Handbook (Second Edition), 2014 Abstract High-density lipoprotein (HDL) is the most complex class of lipoproteins. HDL is comprised of several subclasses that are different in size, protein and lipid composition, physiological functions, and pathophysiological significance. Although HDL has been studied for at least half a century, its roles in diseases are poorly understood. Recently, with the rapid development of analytical techniques, much has been learned about HDL composition, especially about HDL proteomics.

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